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Sturman and Stevenson, reported the first Italian case on March 2, with recent confirmations of cases from all over the country. Italian Health Authorities contact the World Health Organization (WHO) on March 11, 2016 followed by the Regional Health Department on the 12th. In particular, the Italian National Institute for Health (ISS) published the first announcement on March 13. After the notification, two new cases were diagnosed (1).
Altogether, Italian Department of Civil Protection estimated the new total number of cases on the 14th, including a cluster of 254 infected people in the province of Messina (Lombardy) and a cluster of 131 people in the province of Teramo (Abruzzo). Approximately 80 people are hospitalized, of which about 30% show severe clinical picture. Specimens were tested from five patients, two of whom are a mother and her infant, and one single-parent. In particular, the newborn was asymptomatic; the mother had flu-like symptoms without fever, and hospitalization for respiratory problems in February (!). Indeed, COVID-19 can be diagnosed even in newborns with no clinical evidence, as reported by Shu X et al. A same study also demonstrates that the newborn with symptoms may have positive RT-PCR, pointing that SARS-CoV-2 is able to infect the fetus. Furthermore, a recent study reported the SARS-CoV-2 detection on the surface of placental cells, thus showing that placental transmission of SARS-CoV-2 might occur. Coincidentally, the authors of this paper also report in situ hybridization of SARS-CoV-2 in the villous cytoplasm and nuclei of the placental cells. Therefore, the authors of this study propose that vertical transmission of SARS-CoV-2 may occur from mother to neonate through the placenta with possible negative consequences for the newborn. While Lee K et al. reported the first case of COVID-19 in a pregnant woman with severe disease. Remarkably, they described a successful amniocentesis, which showed no viral components in the cells. Thus, the authors conclude that SARS-CoV-2 is not present in the amniotic fluid and the fetus does not manifest any clinical symptoms. d2c66b5586
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